Chinese Association of Idaho State University (CAISU)
Plecanatide Dosage and Administration
Plecanatide Dosage and Administration
Administer orally without regard to food.1 Administration with meals may result in looser stools.If patient cannot swallow whole tablet, crush tablet and mix in applesauce and administer orally or disperse tablet in water and administer orally or via a nasogastric or gastric feeding tube.1 Use these mixtures immediately; do not store for later use.1 Administration in other soft foods or liquids not studied.Plecanatide powder
If a dose is missed, do not double the dose.1 Administer the next dose at the regularly scheduled time.
Oral Administration in Applesauce
Crush 3-mg tablet to a powder and mix with 1 teaspoonful of room-temperature applesauce.1 Administer entire mixture immediately.
Oral Administration as Aqueous Dispersion
Place 3-mg tablet in a cup, add approximately 30 mL of room-temperature water, gently swirl for ≥10 seconds to disperse the disintegrating tablet, then administer immediately.
Disperse any residue remaining in the cup in an additional 30 mL of water, gently swirl for ≥10 seconds, then administer immediately.
Administration via Nasogastric or Gastric Tube
Place 3-mg tablet in a cup, add approximately 30 mL of room-temperature water, gently swirl for ≥15 seconds to disperse the disintegrating tablet.1 Flush the nasogastric or gastric feeding tube with 30 mL of water, then draw up entire contents of the plecanatide dispersion into a syringe and administer immediately.
Disperse any residue remaining in the cup in an additional 30 mL of water, gently swirl for ≥15 seconds, and administer using the same syringe.1 Then use the same syringe or a new syringe to flush the nasogastric or gastric feeding tube with ≥10 mL of water.
Administer orally without regard to food.1 Administration with meals may result in looser stools.If patient cannot swallow whole tablet, crush tablet and mix in applesauce and administer orally or disperse tablet in water and administer orally or via a nasogastric or gastric feeding tube.1 Use these mixtures immediately; do not store for later use.1 Administration in other soft foods or liquids not studied.Plecanatide powder
If a dose is missed, do not double the dose.1 Administer the next dose at the regularly scheduled time.
Oral Administration in Applesauce
Crush 3-mg tablet to a powder and mix with 1 teaspoonful of room-temperature applesauce.1 Administer entire mixture immediately.
Oral Administration as Aqueous Dispersion
Place 3-mg tablet in a cup, add approximately 30 mL of room-temperature water, gently swirl for ≥10 seconds to disperse the disintegrating tablet, then administer immediately.
Disperse any residue remaining in the cup in an additional 30 mL of water, gently swirl for ≥10 seconds, then administer immediately.
Administration via Nasogastric or Gastric Tube
Place 3-mg tablet in a cup, add approximately 30 mL of room-temperature water, gently swirl for ≥15 seconds to disperse the disintegrating tablet.1 Flush the nasogastric or gastric feeding tube with 30 mL of water, then draw up entire contents of the plecanatide dispersion into a syringe and administer immediately.
Disperse any residue remaining in the cup in an additional 30 mL of water, gently swirl for ≥15 seconds, and administer using the same syringe.1 Then use the same syringe or a new syringe to flush the nasogastric or gastric feeding tube with ≥10 mL of water.
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