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In clinical trials using combination therapy with NEXIUM plus amoxicillin and clarithromycin, no additional increased laboratory abnormalities particular to these nexium drug combinations were observed .
The most frequently occurring adverse nexium reactions ( ? 1%) in all three groups were headache (5 . The safety in the treatment of healing of erosive esophagitis was assessed in four randomized comparative clinical trials, which included 1,240 patients on NEXIUM 20 nexium mg, 2,434 patients on NEXIUM 40 mg, and 3,008 patients on omeprazole 20 mg daily . 5, 5, nexium and 3 . 8, respectively) and diarrhea (no difference among the three nexium groups) . Nausea, flatulence, abdominal pain, constipation, and dry mouth occurred at similar nexium rates among patients taking NEXIUM or omeprazole .

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