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When extrapolated to the maximum recommended tapentadol daily dose, a mean clinical AUC value of 2502 ng . h/mL (tapentadol IR) was obtained11 AUC-based exposure comparisons were made based on values calculated from time zero to infinity (0-∞) or from time zero to a pre-define time t (0-t), with a preference for tapentadol the former, wherever possible; the values for t in each study are specified in Table 2 .
The first dose in the sequence was given for 3 days, the tapentadol second for the next 11 days and the third dose was given for the final 2 weeks of the study .
The effects in rats were prevented by co-administration nucynta and methadone nucynta er 100mg tapentadol colombia tapentadol que es tapentadol how long to of naloxone .
Renal Impairment tapentadol For patients with mild or moderate renal impairment, no dosage adjustment is recommended (see DOSAGE AND ADMINISTRATION) .

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