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There was no evidence of naltrexone teratogenicity when naltrexone was administered orally to rats and rabbits during the period of major organogenesis at doses up to 200 mg/kg/day (32 and 65 times the recommended therapeutic dose, respectively, based on body surface area) . Naltrexone has been shown naltrexone to increase the incidence of early fetal loss when given to rats at doses ? 30 mg/kg/day (180 mg/m?/day; 5 times the recommended therapeutic dose, based on body surface area) and to rabbits at oral doses ? 60 mg/kg/day (720 mg/m?/day; 18 times the recommended therapeutic dose, based on body surface area) .
REVIA and its primary metabolite are excreted primarily in the urine, and caution is recommended in buy nodict naltrexone buy naltrexone 3mg buy naltrexone south africa buy naltrexone usa buy administering the drug to patients with renal impairment .

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