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Usage of methotrexate:

With IV administration, 80% to 90% of the administered methotrexate dose is excreted unchanged in the urine within 24 hours . Renal excretion methotrexate is the primary route of elimination and is dependent upon dosage and route of administration . Enterohepatic recirculation of methotrexate methotrexate has been proposed . There is limited biliary methotrexate excretion amounting to 10% or less of the administered dose .
In patients with rheumatoid arthritis, effects of methotrexate on articular swelling and tenderness methotrexate can be seen as early as 3 to 6 weeks . Although methotrexate clearly ameliorates methotrexate symptoms of inflammation (pain, swelling, stiffness), there is no evidence that it induces remission of rheumatoid arthritis nor has a beneficial effect been demonstrated on bone erosions and other radiologic changes which result in impaired joint use, functional disability, and deformity .

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