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CRESTOR has not been studied in controlled clinical trials involving prepubertal patients or patients younger than 10 years of age with heterozygous familial crestor hypercholesterolemia . However, the safety and effectiveness of CRESTOR were evaluated in a two year open-label uncontrolled trial that crestor included children and adolescents 8 to 17 years of age with heterozygous familial hypercholesterolemia [see Clinical Studies] . The safety and efficacy of crestor CRESTOR in lowering LDL-C appeared generally consistent with that observed for adult patients, despite limitations of the uncontrolled study design .
Table 1: Adverse Reactions Reported in ? 2% of Patients crestor Treated with CRESTOR and > Placebo in Placebo-Controlled Trials (% of Patients ) .

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