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[53] It is usually reserved as a second-line treatment for depression due to a combination of its superior efficacy to the first-line treatments like fluoxetine, effexor paroxetine and citalopram and greater frequency of side effects like nausea, headache, insomnia, drowsiness, dry mouth, constipation, sexual dysfunction, sweating and nervousness . Most patients overdosing effexor with venlafaxine develop only mild symptoms . [52] Published retrospective studies report that venlafaxine overdosage may be associated with an increased risk of fatal outcome compared to that missed effexor dose side effects how long does it take for effexor to kick in what time of day observed with SSRI antidepressant products, but lower than that for tricyclic antidepressants . Healthcare professionals are advised to prescribe Effexor and how long does it take for effexor to kick in why has effexor been discontinued in the us is effexor Effexor XR in the smallest quantity of capsules consistent with good patient management to reduce the risk of overdose . Plasma venlafaxine concentrations in overdose survivors have ranged from 6 to 24 mg/l, while postmortem blood levels in fatalities are often in the 10�90 effexor mg/l range .

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