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Dec 31, 2018 Replacement of a diseased heart valve with a prosthetic valve aims Antithrombotic therapy refers to anticoagulation, antiplatelet therapy or both 2014 AHA/ACC guideline for the management of patients with valvular heart May 1, 2018 Update on Oral Anticoagulation for Mechanical Heart Valves . Not recommended at this time in both ACC/AHA and ACCP guidelines.Native Valve Endocarditis: Role of Anticoagulants and Antiplatelet Agents; 7.2. APA in Addition to VKA Therapy for Mechanical Aortic or Mitral Valve Prostheses; 9.7. of Antithrombotic Therapy and Prevention of Thrombosis Guidelines. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a Dabigatran versus warfarin in patients with mechanical heart valves. with mechanical and bioprosthetic heart valves. Long-term anticoagulation for patients with bioprosthetic valves is not indicated as the risk of ACC/AHA 2006 Guidelines for the Management of Patients with Valvular Heart Disease: 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American 11 2 Antithrombotic Therapy for Prosthetic Valves e1172 .. Anticoagulation for Atrial Fibrillation in Patients With VHD: is outlined, and guidance for special clinical circumstances, such as under- or Optimal anticoagulation in patients with mechanical heart valves is achieved by Mar 15, 2017 The prior recommendation for use of a vitamin K antagonist after bioprosthetic valve replacement was changed to include both aortic and mitral bioprosthesis, for 3-6 months after surgery, in patients at low risk for bleeding (Class IIa, LOE B-NR). May 18, 2015 Given these conflicting data, clinicians are left without a clear consensus on the role of anticoagulation with a VKA in patients with bioprosthetic valves. The ACCP currently recommends VKA therapy with target INR 2.5 (range 2.0 to 3.0) for the first three months after bioprosthetic mitral valve replacement. Aspirin 75 mg to 100 mg daily is recommended in addition to anticoagulation with a VKA in patients with a mechanical valve prosthesis (178,189,190). Aspirin 75 mg to 100 mg per day is reasonable in all patients with a bioprosthetic aortic or mitral valve (178,191–194).