Chinese Association of Idaho State University (CAISU)
The human body has specific sites that are allotted to cannabinoids, called the cannabinoid receptor sites. Receptors are mechanisms to which the cannabinoids naturally present in the human body as well as the ones artificially ingested/ applied attach themselves. There are two kinds of receptors for cannabinoids, the CB1, and the CB2. While the CB1 receptors are present in the brain, the CB2 receptors can be found in the immune system. Cannabinoids can be agonists, inverse agonists or inhibitors. The agonists simply stimulate a bodily function once they adhere to their respective receptors. Inverse agonists associate themselves with the same receptors as agonists, while causing a chemical reaction opposite to the ones caused by agonists. Inhibitors simply stop a chemical reaction or response once bound to their receptors. Cannabidiol is unique, as it does not work with the CB1 or CB2 receptors. It passively influences the working of the Endocannabinoid system, regulating the reception of pain, immune system functions and the process of falling and staying asleep. CBD also amplifies the effect of all cannabinoids that attach to the CB1 receptors. Interestingly, CBD oil protects the body against its own euphoric stimulant. An endogenous cannabinoid, Anandamide, is produced on demand by the human body. ‘Ananda’, in Sanskrit, means ‘bliss’. Anandamide, thus, creates a runner’s high, and this is regulated by Cannabidiol. Thus, we feel falsified pleasureless, on the use of cannabidiol or CBD oil. CBD is also said to have anti-tumorous properties. GPR55, a receptor that has shown to proliferate cell production and play a role in cancer, is inhibited by cannabidiol. More research is required to establish the connection between CBD and GPR55 as well as the possible consequences.